Anti-LH-beta (Luteinizing Hormone-beta) Monoclonal Antibody

Product Name

Anti-LH-beta (Luteinizing Hormone-beta) Monoclonal Antibody

View all LH beta Antibodies

SKU/Catalog Number

M01115

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-LH-beta (Luteinizing Hormone-beta) Monoclonal Antibody (Catalog # M01115). Tested in IHC applications. This antibody reacts with Human.

Storage & Handling

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cite This Product

Anti-LH-beta (Luteinizing Hormone-beta) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01115)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

Clone: SPM103

Isotype

IgG1, kappa

Immunogen

Recombinant beta sub-unit of human LH

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Does not cross-react with primate, avian or amphibian GR.

Reactive Species

M01115 is reactive to LHB in Human

Applications

M01115 is guaranteed for IHC Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

15.345kDa

Background of LH beta

Luteinizing hormone (LH) is a glycoprotein. Each monomeric unit is a sugar-like protein molecule; two of these make the full, functional protein. Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta subunit of hCG and both stimulate the same receptor; however, the hCG beta subunit contains an additional 24 amino acids and the hormones differ in the composition of their sugar moieties.LH is synthesized and secreted by gonadotrophs in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle-stimulating hormone (FSH), it is necessary for proper reproductive function. In the female, an acute rise of LH levels triggers ovulation. In the male, where LH has also been called Interstitial Cell-Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Reconstitute with distilled water.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml
30 min RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Validation Images & Assay Conditions

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Formalin-fixed, paraffin-embedded human Pituitary stained with Anti-LH-beta Mouse Monoclonal Antibody (SPM103)

Gene/Protein Information For LHB (Source: Uniprot.org, NCBI)

Alternative Names

CGB4; hLHB; interstitial cell stimulating hormone, beta chain; LH beta; LHB; LSH-B; LSH-beta; luteinizing hormone beta polypeptide; luteinizing hormone beta subunit; lutropin beta chain; Lutropin beta; lutropin subunit beta LHB CGB4, HH23, LSH-B, LSH-beta luteinizing hormone subunit beta lutropin subunit beta|interstitial cell stimulating hormone, beta chain|luteinizing hormone beta polypeptide|luteinizing hormone beta subunit|lutropin beta chain

For more info on LHB, check out the LHB Infographic

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In this infographic, you will see the following information for LHB: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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